Introduction
Recombinant Mouse CD120b/TNFRSF1B/TNFR2 Protein, also known as tumor necrosis factor receptor 2 (TNFR2), is a protein that plays a crucial role in the immune system. This protein is a member of the tumor necrosis factor receptor superfamily and is encoded by the TNFRSF1B gene. Recombinant Mouse CD120b/TNFRSF1B/TNFR2 Protein is a widely studied protein due to its involvement in various physiological processes and its potential as a therapeutic target for various diseases.
Structure of Recombinant Mouse CD120b/TNFRSF1B/TNFR2 Protein
Recombinant Mouse CD120b/TNFRSF1B/TNFR2 Protein is a transmembrane protein that consists of 461 amino acids with a molecular weight of approximately 52 kDa. It is composed of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains four cysteine-rich repeats, which are important for ligand binding. The intracellular domain contains a death domain, which is responsible for activating downstream signaling pathways upon ligand binding.
Activity of Recombinant Mouse CD120b/TNFRSF1B/TNFR2 Protein
The main function of Recombinant Mouse CD120b/TNFRSF1B/TNFR2 Protein is to bind to its ligand, tumor necrosis factor alpha (TNFα). This binding triggers a signaling cascade that leads to the activation of various cellular responses. The binding of TNFα to Recombinant Mouse CD120b/TNFRSF1B/TNFR2 Protein can result in either cell survival or cell death, depending on the cellular context. In general, TNFα binding to Recombinant Mouse CD120b/TNFRSF1B/TNFR2 Protein leads to the activation of pro-inflammatory pathways, which play a crucial role in the immune response.
Application of Recombinant Mouse CD120b/TNFRSF1B/TNFR2 Protein
Recombinant Mouse CD120b/TNFRSF1B/TNFR2 Protein has been extensively studied for its potential therapeutic applications. Due to its role in the immune response, it has been investigated as a target for various diseases, including autoimmune disorders, cancer, and infectious diseases. Recombinant Mouse CD120b/TNFRSF1B/TNFR2 Protein has also been studied for its potential as a biomarker for disease diagnosis and prognosis.
Autoimmune Disorders
Recombinant Mouse CD120b/TNFRSF1B/TNFR2 Protein has been shown to play a critical role in the development of autoimmune disorders. Autoimmune disorders occur when the immune system mistakenly attacks the body’s own tissues. Studies have shown that blocking the activity of Recombinant Mouse CD120b/TNFRSF1B/TNFR2 Protein can reduce the severity of symptoms in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, and psoriasis.
Cancer
Recombinant Mouse CD120b/TNFRSF1B/TNFR2 Protein has also been investigated as a potential target for cancer therapy. TNFα, the ligand for Recombinant Mouse CD120b/TNFRSF1B/TNFR2 Protein, has been shown to have both pro- and anti-tumor effects. By targeting Recombinant Mouse CD120b/TNFRSF1B/TNFR2 Protein, researchers hope to selectively activate the anti-tumor effects of TNFα, while minimizing its pro-tumor effects. This approach has shown promising results in preclinical studies for various types of cancer, including breast cancer, colon cancer, and melanoma.
Infectious Diseases
Infectious diseases are caused by pathogenic microorganisms, such as bacteria, viruses, and fungi. Recombinant Mouse CD120b/TNFRSF
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